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Medically reviewed by: Dr Kathryn Basford Last reviewed: July 16, 2026 Doctor Dr Kathryn Basford is a graduate of the University of Manchester

Nausea and other stomach and bowel effects were the most common side effects and were mostly mild to moderate

The STEP 1 extension data showed approximately two-thirds of total weight loss regained within one year of discontinuation, emphasizing the chronic nature of obesity and the need for sustained treatment in most cases

Studies have shown that for a majority of patients, 12 24 months of receiving semaglutide will provide sustained and lasting weight loss results

Physical Activity: Regular exercise complements the appetite-suppressing effects of GLP-1 agonists

The best outcome is getting the diagnosis right metabolic, airway, jaw, joint and building a plan that handles each part on its own terms